Endocrine Abstracts

Introduction: Pregnancy involves distinct metabolic stages, initially characterized by maternal anabolism, followed by a catabolic phase driven by placental lactogen and various cytokines, leading to varying degrees of insulin resistance. DM is the most common metabolic disorder linked to pregnancy.Objective: The study aimed to detail the clinical characteristics, obstetric complications, and neonatal outcomes of patients with GDM and their children....

Introduction: T2DM is associated with an increased risk of fractures. This heightened risk is attributed to factors such as prolonged disease duration and chronic glycemic control. Interestingly, despite this increased fracture risk, patients with T2DM often exhibit normal or even elevated BMD compared to non-diabetic individuals. This phenomenon is thought to be a result of reduced bone remodeling, coupled with changes in bone microarchitecture.Objectiv...

The lipodystrophic syndromes are a heterogeneous group of congenital or acquired disorders characterized by either complete or partial lack of adipose tissue with the apparent accumulation of fat in other regions of the body. Their prevalence is low and ranges from 1:200000/500000 and they usually suffer metabolic abnormalities associated with the abnormal distributition of fat such as severe insulin resistance with acantosis and diabetes, progressive liver disease along with ...

Introduction: Detransition is the act of stopping or reversing a gender medical, social or surgical transition. The study’s purpose was to describe our experience with a group of transsexual people in detransition phase.Material and methods: A cohort of 204 people with gender incongruence attending the Identity Gender Unit Hospital Clinico of Valladolid from January 2014 to December 2022 was studied. Seven of those participants detransitioned and we...

Objectives: Some authors have defined subtypes within gestational diabetes (GD) based on the calculation, from glucose and insulin levels during oral glucose overload (OGTT), of indices of insulin sensitivity (Matsuda) and insulin secretion (Stumvoll). Powe et al [1] found that 30% of women with GD had predominantly low insulin secretion, 51% low insulin sensitivity and 18% both (mixed). The aim of this work is to analyze the correlation of these indices with other kn...

Introduction: Biotin is a water-soluble vitamin involved in several and important metabolic processes, recommended daily intake for adults is 30–100 μg/day and normal plasma concentrations are 0.4–1.2 ng/day. Nowadays biotin is being used in inherited metabolic diseases, multiple sclerosis and as a supplement in, over the counter multivitamins widely used for common hair and skin problems. The supraphysiologic biotin intake has produced emerging problems with bi...

Glycosylated haemoglobin (HbA1c) is considered the Gold Standard parameter for evaluating long-term glycemic control in individuals with Diabetes Mellitus (DM). The presence of hemoglobin variants or others conditions that modify its glycosylation, can affect the veracity of its measurement. The detection of these hemoglobinopathies and his knowledge by the clinicians is very important for the correct diagnosis and follow-up. We present the case of a patient who presented a he...

Introduction: ‘Atypia of undetermined significance (AUS) or follicular lesion of undetermined significance’ category is established by The Bethesda System for Reporting Thyroid Cytopathology because of the necessity to report those thyroid fine-needle aspiration (FNA) results that are not easily classified into the benign, suspicious or malignant categories. In most cases, a repeated FNA results in a more definitive interpretation. Estimated risk of malignancy for an...

Introduction: Primary hyperparathyroidism is caused by a single adenoma in 85% of cases. This is why bilateral neck exploration seems to be a very aggressive procedure in a large number of cases. Intraoperative parathyroid hormone (IOPTH) monitoring could be a useful tool in primary hyperparathyroidism surgery allowing a less invasive surgical approach. The aim of our study is to evaluate the possible impact of the measurement of IOPTH during surgery.Met...

Introduction: Although the most common causes of hyperprolactinemia are prolactinoma and iatrogenic, another possible cause is severe primary hypothyroidism, in which the increase of prolactin is a cause of pituitary stimulation by TRH, and can be presented with pituitary hyperplasia.Case report: A 31-year-old woman who comes to endocrinology clinic for hyperprolactinemia, which was detected by symptoms of amenorrhea–galactorrhea. After normal pregn...